Cagrilintide/Semaglutide (Coming Soon) for Weight Loss in Houston
Cagrilintide/semaglutide is a once-weekly injection that pairs two appetite-regulating medications in a single dose: cagrilintide, an amylin analog, and semaglutide, a GLP-1 medication. At Houston Weight Loss Center, we are following its progress closely and plan to offer it to appropriate patients at our Houston, Katy, and Webster locations once it becomes available.
Availability: Cagrilintide/semaglutide is not yet available. It is expected to become available as early as January 2027. In the meantime, semaglutide, tirzepatide, and orforglipron are available today. Contact us to get started.
What Is Cagrilintide/Semaglutide?
Cagrilintide/semaglutide is a fixed-dose combination medication given as a once-weekly injection under the skin. It combines two medications that act on different appetite signals:
- Cagrilintide: a long-acting amylin analog. Amylin is a hormone your pancreas releases along with insulin after you eat, and it helps signal fullness.
- Semaglutide: a GLP-1 medication already widely used for weight loss and type 2 diabetes.
Because both medications come in one injection, patients would take a single weekly dose rather than two separate medications.
How Does It Work?
Amylin is a hormone your pancreas releases along with insulin when you eat. It helps you feel full, slows how quickly your stomach empties, and helps keep blood sugar steady after meals. Cagrilintide is a long-acting version of amylin, designed to keep that fullness signal working throughout the week.
GLP-1 and amylin are both natural hormones that help regulate appetite after meals. Semaglutide acts on GLP-1 receptors to reduce hunger, slow digestion, and help regulate blood sugar. Cagrilintide acts on amylin receptors, which help you feel full sooner and stay satisfied longer. Because the combination targets both pathways, it works on appetite differently than a GLP-1 medication alone. As with every weight loss medication we prescribe, results depend on pairing it with nutrition, activity, and ongoing support.
When Will It Be Available?
Cagrilintide/semaglutide is not currently available for us to prescribe. It is expected to become available as early as January 2027. Once it is, our physician or Nurse Practitioner can help you decide whether it is a good fit for you.
How Does It Compare to Semaglutide and Tirzepatide?
Each of these medications works through a different combination of appetite pathways:
- Semaglutide: GLP-1, once-weekly injection
- Tirzepatide: GLP-1 and GIP, once-weekly injection
- Orforglipron: GLP-1, once-daily pill
- Cagrilintide/semaglutide: GLP-1 and amylin, once-weekly injection
No single medication is right for everyone. Your physician or Nurse Practitioner considers your health history, goals, side effects, and cost when recommending a medication. Once cagrilintide/semaglutide is available, they can also help you decide whether switching makes sense.
Who May Be a Candidate?
Cagrilintide/semaglutide is being developed for adults who are overweight or obese, used alongside a reduced-calorie diet and increased physical activity. Whether it is appropriate for you will be decided together with our physician or Nurse Practitioner after a medical evaluation.
As with other GLP-1 medications, it is not expected to be appropriate for people who are pregnant, planning to become pregnant, or breastfeeding, or for anyone with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Patients with a history of pancreatitis need careful review.
Cagrilintide/Semaglutide Side Effects
Side effects are expected to be similar to those of other GLP-1 medications. The most common are gastrointestinal, tend to be mild to moderate, and usually occur when the dose is increased:
- Nausea
- Vomiting
- Constipation
- Diarrhea
Full prescribing information is not yet available. Your physician or Nurse Practitioner will review it with you before you start.
Start Your Weight Loss Today
You do not need to wait. Our GLP-1 weight loss program offers once-weekly semaglutide and tirzepatide injections and once-daily oral orforglipron today, each physician-directed with monitoring at every step. Your first visit is $199 and includes lab work.
Frequently Asked Questions
Is cagrilintide/semaglutide available at Houston Weight Loss Center?
Not yet. It is not currently available for us to prescribe, but it is expected as early as January 2027. We plan to offer it to appropriate patients at our Houston, Katy, and Webster locations once it is.
When will cagrilintide/semaglutide be available?
It is expected to become available as early as January 2027.
How much will cagrilintide/semaglutide cost?
Pricing has not been announced yet. We will share current pricing once it becomes available.
Can I switch from semaglutide or tirzepatide?
Possibly. Once it is available, your physician or Nurse Practitioner can review how you are doing on your current medication and whether a change makes sense for you.
Is cagrilintide/semaglutide a pill or an injection?
It is a once-weekly injection under the skin, like semaglutide and tirzepatide. If you prefer a pill, ask about orforglipron, a once-daily oral GLP-1 medication.
How do I get started?
Contact us at our Houston, Katy, or Webster location. You can start a GLP-1 weight loss program today and talk with your provider about cagrilintide/semaglutide once it becomes available.